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CVE-2025-12921

28
FAUCET Score

CVE-2025-12921 is an XML injection vulnerability affecting OpenClinica Community Edition versions up to 3.12.2/3.13. Specifically, it resides in the CRF Data Import component, allowing manipulation of the 'xml_file' argument within the /ImportCRFData?action=confirm function. This vulnerability carries a high CVSS score of 8.8, indicating a network-exploitable flaw with low attack complexity, potentially leading to high impact on confidentiality, integrity, and availability. While the exploit has been publicly disclosed, there is no evidence of active exploitation, Metasploit modules, or significant community discussion or media coverage.

Impacted Technologies

VendorProductVersion(s)CPE
3.12.2CPE matchmatch criteria
cpe:2.3:a:openclinica:openclinica:3.12.2:*:*:*:community:*:*:*
3.13CPE matchmatch criteria
cpe:2.3:a:openclinica:openclinica:3.13:*:*:*:community:*:*:*

CVSS Data

CVSS version used by this source: 4.0

2.1LOW

CVSS:4.0/AV:N/AC:L/AT:N/PR:L/UI:N/VC:L/VI:N/VA:N/SC:N/SI:N/SA:N/E:P/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/MVI:X/MVA:X/MSC:X/MSI:X/MSA:X/S:X/AU:X/R:X/V:X/RE:X/U:X

Attack Vector
NETWORK
Attack Complexity
LOW
Attack Requirements
NONE
Privileges Required
LOW
User Interaction
NONE
VS Confidentiality
LOW
VS Integrity
NONE
VS Availability
NONE
SS Confidentiality
NONE
SS Integrity
NONE
SS Availability
NONE
Exploit Maturity
PROOF_OF_CONCEPT
CvssVersion
4.0

Exploit Intelligence

EPSS Score
0.52%
Probability of exploitation in next 30 days
EPSS Percentile
40.9%
Percentile rank of EPSS score among Peer Group
As of 2026-07-27
Model: v2026.06.15
This CVE's current EPSS score of 0.0052 is in the 30th percentile among its peer group of 17,844 CVEs.

Social Chatter

The average CVE in this peer group has 0.0 Twitter, 0.0 Reddit, 0.3 Bluesky, 0.1 Mastodon, and 0.2 GitHub mentions.

Media Mentions

No media coverage found for this CVE.

The average CVE in this peer group has 0.1 InfoSec Media, 0.0 Vendor Blog, and 0.0 Security Researcher mentions.

Remediation

Remediation records are not available for this CVE.

References

github.com / mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md
ExploitThird Party Advisory
github.com / mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md
ExploitThird Party Advisory
vuldb.com
Permissions RequiredVDB Entry
vuldb.com
Third Party AdvisoryVDB Entry
vuldb.com
Third Party AdvisoryVDB Entry