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CVE-2022-1521

22
FAUCET Score

CVE-2022-1521 is a critical vulnerability affecting multiple Illumina genetic analysis devices, including iSeq 100, Local Run Manager, and MiSeq models. The flaw stems from a lack of default authentication and authorization in the Local Run Manager (LRM) software. This allows an unauthenticated attacker to remotely inject, replay, modify, or intercept sensitive data over the network with low attack complexity. While the vulnerability has a CVSS score of 9.1 (Critical) and a high FAUCET Risk Score of 72/100, there is no evidence of active exploitation, and no public exploit code is available. Community discussion and media coverage are minimal, with only one mention and one article identified.

Impacted Technologies

VendorProductVersion(s)CPE
>= 1.3, <= 3.1CPE matchmatch criteria
cpe:2.3:a:illumina:local_run_manager:*:*:*:*:*:*:*:*

CVSS Data

CVSS version used by this source: 3.1

9.1CRITICAL

CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:N

Attack Vector
NETWORK
Attack Complexity
LOW
Privileges Required
NONE
User Interaction
NONE
Scope
UNCHANGED
Confidentiality Impact
HIGH
Integrity Impact
HIGH
Availability Impact
NONE
Exploitability Score
3.9
Impact Score
5.2
CvssVersion
3.1

Exploit Intelligence

EPSS Score
1.03%
Probability of exploitation in next 30 days
EPSS Percentile
60.2%
Percentile rank of EPSS score among Peer Group
As of 2026-07-27
Model: v2026.06.15
This CVE's current EPSS score of 0.0103 is in the 45th percentile among its peer group of 36,897 CVEs.

Social Chatter

No social media mentions found for this CVE.

The average CVE in this peer group has 0.0 Twitter, 0.1 Reddit, 0.3 Bluesky, 0.3 Mastodon, and 2.4 GitHub mentions.

Media Mentions

The average CVE in this peer group has 0.3 InfoSec Media, 0.0 Vendor Blog, and 0.0 Security Researcher mentions.

Remediation

Remediation records are not available for this CVE.

References

cisa.gov / uscert/ics/advisories/icsa-22-153-02
Third Party AdvisoryUS Government Resource