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CVE-2022-1518

30
FAUCET Score

CVE-2022-1518 is a critical directory traversal vulnerability affecting Illumina's Local Run Manager (LRM) and several associated genetic analysis devices, including iSeq 100, MiniSeq, MiSeq, and NextSeq platforms. With a CVSS score of 9.8, this vulnerability allows an unauthenticated attacker to upload files outside the intended directory structure over the network with low complexity, potentially leading to complete compromise of confidentiality, integrity, and availability. While there is no known active exploitation or public exploit code (Metasploit, Nuclei, ExploitDB), the vulnerability has garnered significant community discussion and media coverage, including a CISA warning, indicating high awareness and potential for future exploitation.

Impacted Technologies

VendorProductVersion(s)CPE
>= 1.3, <= 3.1CPE matchmatch criteria
cpe:2.3:a:illumina:local_run_manager:*:*:*:*:*:*:*:*

CVSS Data

CVSS version used by this source: 3.1

10.0CRITICAL

CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:C/C:H/I:H/A:H

Attack Vector
NETWORK
Attack Complexity
LOW
Privileges Required
NONE
User Interaction
NONE
Scope
CHANGED
Confidentiality Impact
HIGH
Integrity Impact
HIGH
Availability Impact
HIGH
Exploitability Score
3.9
Impact Score
6.0
CvssVersion
3.1

Exploit Intelligence

EPSS Score
1.51%
Probability of exploitation in next 30 days
EPSS Percentile
71.7%
Percentile rank of EPSS score among Peer Group
As of 2026-07-26
Model: v2026.06.15
This CVE's current EPSS score of 0.0151 is in the 59th percentile among its peer group of 36,835 CVEs.

Social Chatter

The average CVE in this peer group has 0.0 Twitter, 0.1 Reddit, 0.3 Bluesky, 0.3 Mastodon, and 2.4 GitHub mentions.

Media Mentions

The average CVE in this peer group has 0.3 InfoSec Media, 0.0 Vendor Blog, and 0.0 Security Researcher mentions.

Remediation

Remediation records are not available for this CVE.

References

cisa.gov / uscert/ics/advisories/icsa-22-153-02
Third Party AdvisoryUS Government Resource